Doç. Dr. Erdem Aktaş
Serum TNF-alpha levels: potential use to indicate osteoarthritis progression in a mechanically induced model (English)
To investigate plasma tumor necrosis factoralpha (TNF-a) levels as an indicator to reflect the magnitude of the destructive inflammatory phase and articular cartilage damage after a knee trauma. Eighteen mature Wistar Albino male rats were divided into two groups equal in number. Nine animals underwent anterior cruciateligament transection (ACLT) of the right knees, while nine animals had a sham procedure.
Mechanically induced experimental knee osteoarthritis benefits from anti-inflammatory and immunomodulatory properties of simvastatin via inhibition of matrix metalloproteinase-3 (English)
We investigated the anti-inflammatory and immunomodulatory effect of simvastatin on articular cartilage via the inhibition of matrix metalloproteinase-3 (MMP-3), a matrix-degrading enzyme, in a mechanically induced experimental osteoarthritis (OA) animal model. Materials and methods Twenty-seven albino Wistar rats
Polysaccharide hemostatic system reduces blood loss in high-body-mass-index patients undergoing simultaneous bilateral total knee arthroplasty. (English)
By reducing blood loss and the need for postoperative blood transfusion in patients with high BMI, PHA can be of value as adjuvant therapy in new blood-management procedures in major joint-replacement surgery
Platelet-rich plasma versus corticosteroid injections for carpal tunnel syndrome (English)
Platelet-rich plasma therapy has the potential to promote peripheral nerve regeneration through the autologous supply of growth factors. Therefore, this study aimed to compare the effects of platelet-rich plasma injections with the effects of corticosteroid injections in the treatment of carpal tunnel syndrome.
Serum and knee synovial fluid matrix metalloproteinase-13 and tumor necrosis factor-alpha levels in patients with late-stage osteoarthritis (English)
Despite the systemic increase in TNF-α levels concordant with osteoarthritis grade, MMP-13 levels are elevated via local manner, with a significant correlation with WOMAC scores.
Impact of oxidative stress on early postoperative knee function and muscle injury biochemical markers: Is it possible to create an ischemic preconditioning effect in sequential ischemic surgical procedures? (English)
The biochemical and functional outcomes can be attributed to potential IPC effect. During bilateral TKA, a 20-minute interval between tourniquets can create IPC effect and attenuate the magnitude of ischemia-reperfusion injury, preserving better functional outcomes.
Impact of Alprazolam on Comorbid Pain and Knee Functions in Total Knee Arthroplasty Patients Diagnosed with Anxiety and Depression (English)
Alprazolam can reduce postoperative analgesic use and improve knee functions by reducing the pain threshold, and enhancing overall mood via its antidepressive and anxiolytic properties in patients undergoing TKA diagnosed with mild-moderate anxiety/depression.
Grade of coracoacromial ligament degeneration as a predictive factor for impingement syndrome and type of partial rotator cuff tear (English)
Grade 1 and grade 2 coracoacromial ligament degeneration is a strong predictive factor for impingement syndrome in the etiology of bursal-side partial cuff tears and can guide the surgeon to consider ligament release and débridement or acromioplasty in these patients.
Do corrective shoes improve the development of the medial longitudinal arch in children with flexible flat feet? (English)
Corrective shoes for flexible flatfoot was found not effective on development of foot arches. Therefore, they should be limited only for selected cases.
Comparison of multimodal intraoperative neurophysiological monitoring efficacy in early childhood and school aged children undergoing spinal surgery (English)
Compared to school aged children, both SSEPs, tcMEPs recordings are feasible and MIONM is effective for early childhood patients undergoing spinal surgery.
Biomechanical Evaluation of a Novel Apatite-Wollastonite Ceramic Cage Design for Lumbar Interbody Fusion: A Finite Element Model Study (English)
Biomechanical analyses suggest that K2 bioceramic cage is an optimal design and reveals essential material properties for a stable interbody fusion.
Surgical management of bone metastases from urological malignancies: an analysis of 70 cases (English)
Detection of bone metastases in patients with urological malignancies influences the treatment strategy. Diagnosis of bone metastases may be delayed in urologic malignities; thus, these patients receive long-term clinical follow-up.
Isolated scapula fracture: Ice hockey player without trauma (English)
Scapular fractures are generally seen along with other injuries, but in this case we wanted to emphasize that care has to been taken to diagnose an isolated scapular fracture while assessing shoulder pain.
Chondromyxoid fibroma of the pubic ramus: a case report and literature review (English)
Chondromyxoid fibromas (CMF) are benign cartilaginous bone tumors which are found most frequently in the metaphyses of long bones. They comprise less than 1% of primary bone neoplasms. We report an interesting incidental case of a 43-year-old woman with a CMF of the left pubic ramus, presenting with complaints of gradual onset of left groin pain over a period of 2 years. According to radiological examination, a malign chondroid bone tumor was excluded, and histopathological examination confirmed the
Chondroblastoma of the Medial Cuneiform Bone in a 32-Year-Old Woman (English)
A painful, expansile, thin, sclerotic lesion detected at the cuneiform should arise suspicion for chondroblastoma even at age over 20 years. Meticulous curettage of the lesion from a small window with removal of the lesion followed by injectable phosphocalcic cement application with autologous PRP can be considered as a curativeand technically simple treatment method.
Primed Mesenchymal Stem Cells Alter and Improve Rat Medial Collateral Ligament Healing (English)
MSC therapy for ligaments and tendons have varying results with some studies demonstrating enhanced healing, while others show no improvement. This is one of the challenges when working with MSCs and relates to the fact that cellsmay differ in quality based on collection andmanufacturingmethods. Priming activates cells and has the potential toincrease their efficacy.
Mesenchymal Stem Cell Therapy on Tendon/Ligament Healing (English)
In conclusion, ligament and tendon injuries are a prevalent problem, frequently resulting in scar formation and compromised function. MSC treatment can attenuate some of these issues. It improves ligament and tendon strength and provides a more favorable type I collagen composition, indicating a beneficial therapeutic response to these cells.
Immune Modulation With Primed Mesenchymal Stem Cells Delivered Via Biodegradable Scaffold to Repair an Achilles Tendon Segmental Defect (English)
this study shows the potency of MSC’s immunomodulatory paracrine secretion and its promise for future cell-based therapies. MSCs have the potential to regulate multiple cell types arising in multiple pathologic scenariosinvolving inflammation and immunity.