Mechanically induced experimental knee osteoarthritis benefits from anti-inflammatory and immunomodulatory properties of simvastatin via inhibition of matrix metalloproteinase-3

Language
English

Authors
Erdem Aktas • Ertugrul Sener • Pınar Uyar Gocun

Summary
We investigated the anti-inflammatory and immunomodulatory effect of simvastatin on articular cartilage via the inhibition of matrix metalloproteinase-3 (MMP-3), a matrix-degrading enzyme, in a mechanically induced experimental osteoarthritis (OA) animal model. Materials and methods Twenty-seven albino Wistar rats

Keywords
Simvastatin, Anterior cruciate ligament, Knee Osteoarthritis, Knee Osteoarthritis Treatment, Matrix Metalloproteinase-3